search_inactive_compounds Inactive small-molecule compound-target pairs. search_failed_selectivity Small molecules that failed selectivity. search_admet_failures Small-molecule ADMET failures. search_failed_guides Failed/ineffective CRISPR guides. search_failed_essentiality_screens Non-dependency / failed essentiality screens. search_ancestry_specific_failures Ancestry-specific CRISPR failures. search_developability_failures Antibody developability failures. search_failed_clinical_antibodies Discontinued/terminated clinical antibodies. search_failed_peptide_therapeutics Failed peptide therapeutics. search_peptide_stability_issues Peptide stability/half-life failures. search_failed_protacs PROTACs that failed degradation/ternary/permeability. search_protac_e3_issues PROTAC E3-ligase recruitment / ternary failures. search_failed_oligonucleotides ASOs/siRNAs that failed engagement/developability. search_oligo_delivery_failures Oligonucleotide delivery failures. search_failed_vaccines Failed/terminated vaccines (by pathogen/indication). search_vaccine_immunogenicity_failures Failed vaccine immunogen designs. search_failed_adcs ADCs that failed at any stage. search_adc_linker_failures ADC failures attributed to linker chemistry. search_failed_bispecifics Bispecifics that failed at any stage. search_bispecific_format_failures Bispecific format/engineering failures. search_admet_failures_all_modalities ADMET failures across ALL modalities. search_drug_drug_interaction_failures Drug-drug interaction failures. search_mechanism_failures Approaches that failed for a mechanism (by target). search_failed_replications Findings that failed to replicate. search_safety_failures Clinical/preclinical safety failures across modalities. search_target_history ALL failed approaches against a target across every modality. search_indication_history ALL failed approaches for an indication across every modality. search_pathogen_history Vaccine + antimicrobial + antibody failures for a pathogen. get_compound A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources. get_finding_provenance Full provenance + detail for a single finding by id. get_target_landscape Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533). list_top_targets Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other). list_models Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC. get_model_card Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533). get_coverage Per-modality and per-source coverage stats (honest Phase-1 numbers). 